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Use with digoxin: improve the hazard of digoxin toxicity. Use with CYP3A inhibitors (other than ritonavir): improve the risk of adverse reactions of alprazolam. Use with CYP3A inducers: boost the hazard of lessened efficacy of Xanax.
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Use with opioids: boost the hazard of respiratory depression. Use with other CNS depressants: makes additive CNS depressant consequences.
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